Phenotypes associated with this allele

• Allele Symbol: Rr29^tm1.1Bobh
• Allele Name: targeted mutation 1.1, Robert E Hill
• Allele ID: MGI:5613147
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr29^tm1.1Bobh/Rr29^tm1.1Bobh	involves: 129P2/OlaHsd	MGI:5613157
cx2	Rr29^tm1.1Bobh/Rr29^+ Shh^tm1Chg/Shh^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5613161

Genotype
MGI:5613157

hm1

• Allelic Composition: Rr29^tm1.1Bobh/Rr29^tm1.1Bobh
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

oligodactyly ( J:208849 )

• 23% of mice have 4 digits, 27% have 4 phalanges and 3 metatarsels, 41% have 3 digits and 9% have 3 sets of phalanges and 2 metatarsels

abnormal tarsal bone morphology ( J:208849 )

• loss or fusion of tarsals

fused tarsal bones ( J:208849 )

short forelimb ( J:208849 )

• severe forelimb truncations

abnormal hindlimb zeugopod morphology ( J:208849 )

• range of hind limb phenotypes including thickening, shortening and often fusions of the tibia and fibula

abnormal metatarsal bone morphology ( J:208849 )

• loss of metatarsals often showing fusions

fused metatarsal bones ( J:208849 )

skeleton

abnormal tarsal bone morphology ( J:208849 )

• loss or fusion of tarsals

fused tarsal bones ( J:208849 )

abnormal metatarsal bone morphology ( J:208849 )

• loss of metatarsals often showing fusions

fused metatarsal bones ( J:208849 )

Genotype
MGI:5613161

cx2

• Allelic Composition: Rr29^tm1.1Bobh/Rr29⁺; Shh^tm1Chg/Shh⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

limbs/digits/tail

abnormal limb morphology ( J:208849 )

• range of limb phenotypes similar to mice homozygous for Rr29^tm1.1Bobh

oligodactyly ( J:208849 )

• 40% of mice have 4 digits, 30% have 4 phalanges and 3 metatarsels, 10% have 3 digits and 20% have 3 sets of phalanges and 2 metatarsels