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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam23tm1.1Mejr
targeted mutation 1.1, Dies Meijer
MGI:5613204
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adam23tm1.1Mejr/Adam23tm1.1Mejr
Pvalbtm1(cre)Arbr/Pvalb+ 		involves: 129P2/OlaHsd MGI:7444419
cn2
 		Adam23tm1.1Mejr/Adam23tm1.1Mejr
Tg(Dhh-cre)1Mejr/0 		involves: FVB/N MGI:7444421
cn3
 		Adam23tm1.1Mejr/Adam23tm1.1Mejr
Tg(Avil-icre/ERT2)AJwo/0 		Not Specified MGI:7444422


Genotype
MGI:7444419
cn1
Allelic
Composition		 Adam23tm1.1Mejr/Adam23tm1.1Mejr
Pvalbtm1(cre)Arbr/Pvalb+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam23tm1.1Mejr mutation (0 available); any Adam23 mutation (63 available)
Pvalbtm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:333962 )
N
• mice exhibit normal peripheral axon myelination and Aalphabeta-fiber electrical threshold, amplitude, and conduction velocity
abnormal neuron morphology ( J:333962 )
• absent Kv1 channels complex accumulation at the juxtaparanodal membrane in neurons
abnormal neuron physiology ( J:333962 )
• application of 4-AP does not further prolong the refractory period in sensory root neurons unlike in wild-type mice

behavior/neurological
abnormal gait ( J:333962 )
• after 6 to 8 weeks




Genotype
MGI:7444421
cn2
Allelic
Composition		 Adam23tm1.1Mejr/Adam23tm1.1Mejr
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam23tm1.1Mejr mutation (0 available); any Adam23 mutation (63 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:333962 )
N
• mice exhibit normal Kv1 channel complex protein at the juxtaparanodal membrane in sciatic nerves




Genotype
MGI:7444422
cn3
Allelic
Composition		 Adam23tm1.1Mejr/Adam23tm1.1Mejr
Tg(Avil-icre/ERT2)AJwo/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam23tm1.1Mejr mutation (0 available); any Adam23 mutation (63 available)
Tg(Avil-icre/ERT2)AJwo mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:333962 )
• Kv1 channel complex protein disappear form the juxtaparanodal membrane between 10- and 29-weeks post-tamoxifen treatment




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory