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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bmal1tm1.2Shbi
targeted mutation 1.2, Shigeki Shimba
MGI:5613363
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bmal1tm1.2Shbi/Bmal1tm1.2Shbi involves: C57BL/6J MGI:5613396


Genotype
MGI:5613396
hm1
Allelic
Composition
Bmal1tm1.2Shbi/Bmal1tm1.2Shbi
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmal1tm1.2Shbi mutation (0 available); any Bmal1 mutation (139 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in mice fed a high fat diet

vision/eye

homeostasis/metabolism
N
• in the presence of excess insulin, mice exhibit normal blood glucose clearance rate
• mice fed a high fat diet exhibit almost constant weight after 4 weeks unlike wild-type mice that continue to gain weight
• under both light/dark and dark/dark conditions
• 2 times the liver insulin levels observed in wild-type mice
• after glucose or glibenclamide administration
• however, liver insulin content is increased
• during a glucose tolerance test
• reduced triglyceride to cholesterol molar ratio
• increased LDL cholesterol to HDL cholesterol ratio
• in mice are fed standard chow
• in mice are fed a high fat diet
• in mice are fed a high fat diet
• in mice are fed standard chow or a high fat diet
• in mice are fed standard chow or a high fat diet
• when mice are fed a high fat diet
• in mice are fed standard chow
• in mice fed standard chow and more so in mice fed a high fat diet
• increased circulating LDL and HDL triglyceride in mice fed a standard diet or a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• meibomian gland circadian 3beta-hydroxyl-steroid dehydrogenase enzymatic activity is constantly low, with no significant elevation at zeitgeber time 03 compared to wild-type mice which show peaks at zeitgeber time 03
• mice show age-related decline in coenzyme NAD+ levels in the meibomian gland

growth/size/body
• when mice are fed standard chow
• mice fed a high fat diet exhibit almost constant weight after 4 weeks unlike wild-type mice that continue to gain weight

adipose tissue
• after 5 weeks on a high fat diet
• in mice are fed a high fat diet

behavior/neurological
N
• mice exhibit normal food intake whether fed standard chow or a high fat diet
• loss of circadian rhythm in locomotor activity

liver/biliary system
• in mice fed a high fat diet

endocrine/exocrine glands
• increased area at 44 weeks
• however, area is normal at 12 weeks
• after glucose or glibenclamide administration
• however, liver insulin content is increased
• excess sebum in mice fed a high fat diet

integument
• excess sebum in mice fed a high fat diet





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory