Phenotypes associated with this allele

• Allele Symbol: Celsr1^ctb-2J
• Allele Name: curly tail bobber 2 Jackson
• Allele ID: MGI:5613368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Celsr1^ctb-2J/Celsr1^ctb-2J	STOCK Celsr1^ctb-2J/GrsrJ	MGI:5751481

Genotype
MGI:5751481

hm1

• Allelic Composition: Celsr1^ctb-2J/Celsr1^ctb-2J
• Genetic Background: STOCK Celsr1^ctb-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:229303 )

• heterozygous intercrosses generate on average only 10% affected progeny, indicative of death in utero

prenatal lethality, incomplete penetrance ( J:229303 )

• heterozygous intercrosses generate on average fewer than 15% affected progeny, indicative of death in utero

endocrine/exocrine glands

testicular atrophy ( J:229303 )

♂ • histology of one 4-month-old and one 6-month-old male found testicular atrophy and giant nuclei in the epididymis

nervous system

hydrocephaly ( J:229303 )

• mild hydrocephalus found by histology of one 4-month-old and one 6-month-old

growth/size/body

decreased body size ( J:229303 )

reproductive system

testicular atrophy ( J:229303 )

♂ • histology of one 4-month-old and one 6-month-old male found testicular atrophy and giant nuclei in the epididymis

reduced fertility ( J:229303 )

• homozygotes seldom breed, but they do have a normal lifespan

limbs/digits/tail

curly tail ( J:229303 )

behavior/neurological

head tossing ( J:229303 )

• this phenotype ranges from mild to severe

circling ( J:229303 )

• this phenotype ranges from mild to severe

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:229303 )

• moderate to severe hearing loss wsa found by ABR as early as five-and-a-half weeks of age, the earliest timepoint assessed

impaired hearing ( J:229303 )

deafness ( J:229303 )

increased susceptibility to otitis media ( J:229303 )

• histology found otitis media in all ears assessed from 6 weeks to 6 months of age

immune system

increased susceptibility to otitis media ( J:229303 )

• histology found otitis media in all ears assessed from 6 weeks to 6 months of age

integument

abnormal coat appearance ( J:229303 )

• the fur, most noticeably on the rump, can grow in reverse orientation leading to an overall ruffled coat appearance

ruffled hair ( J:229303 )