Phenotypes associated with this allele

• Allele Symbol: Pkn2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5613636
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkn2^tm1b(KOMP)Wtsi/Pkn2^tm1b(KOMP)Wtsi	C57BL/6N-Pkn2^tm1b(KOMP)Wtsi/Ieg	MGI:6263175
ht2	Pkn2^tm1b(KOMP)Wtsi/Pkn2^+	C57BL/6N-Pkn2^tm1b(KOMP)Wtsi/Ieg	MGI:6263174

Genotype
MGI:6263175

hm1

• Allelic Composition: Pkn2^{tm1b(KOMP)Wtsi}/Pkn2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Pkn2^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0319_7_G05

Data Sources

IMPC Data for Pkn2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263174

ht2

• Allelic Composition: Pkn2^{tm1b(KOMP)Wtsi}/Pkn2⁺
• Genetic Background: C57BL/6N-Pkn2^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0319_7_G05

Data Sources

IMPC Data for Pkn2

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HMGU

increased startle reflex ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - HMGU

decreased circulating cholesterol level ( J:211773 )

♀

IMPC - HMGU

decreased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - HMGU

decreased circulating total protein level ( J:211773 )

♀

IMPC - HMGU

decreased circulating unsaturated transferrin level ( J:211773 )

♀

IMPC - HMGU