Phenotypes associated with this allele

• Allele Symbol: Pdhx^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5613640
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdhx^tm1b(EUCOMM)Hmgu/Pdhx^tm1b(EUCOMM)Hmgu	C57BL/6N-Pdhx^tm1b(EUCOMM)Hmgu/Ieg	MGI:6263124
ht2	Pdhx^tm1b(EUCOMM)Hmgu/Pdhx^+	C57BL/6N-Pdhx^tm1b(EUCOMM)Hmgu/Ieg	MGI:6263123

Genotype
MGI:6263124

hm1

• Allelic Composition: Pdhx^{tm1b(EUCOMM)Hmgu}/Pdhx^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Pdhx^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0507_2_E03

Data Sources

IMPC Data for Pdhx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263123

ht2

• Allelic Composition: Pdhx^{tm1b(EUCOMM)Hmgu}/Pdhx⁺
• Genetic Background: C57BL/6N-Pdhx^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0507_2_E03

Data Sources

IMPC Data for Pdhx

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

decreased total retina thickness ( J:211773 )

♀

IMPC - HMGU

abnormal vitreous body morphology ( J:211773 )

♀

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

IMPC - HMGU