Phenotypes associated with this allele

• Allele Symbol: Lama1^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5613672
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lama1^tm2b(EUCOMM)Hmgu/Lama1^tm2b(EUCOMM)Hmgu	C57BL/6N-Lama1^tm2b(EUCOMM)Hmgu/Ieg	MGI:5767708
ht2	Lama1^tm2b(EUCOMM)Hmgu/Lama1^+	C57BL/6N-Lama1^tm2b(EUCOMM)Hmgu/Ieg	MGI:5797624

Genotype
MGI:5767708

hm1

• Allelic Composition: Lama1^{tm2b(EUCOMM)Hmgu}/Lama1^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Lama1^{tm2b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0596_1_A03

Data Sources

IMPC Data for Lama1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5797624

ht2

• Allelic Composition: Lama1^{tm2b(EUCOMM)Hmgu}/Lama1⁺
• Genetic Background: C57BL/6N-Lama1^{tm2b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0596_1_A03

Data Sources

IMPC Data for Lama1

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HMGU

increased startle reflex ( J:211773 )

IMPC - HMGU

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU