Phenotypes associated with this allele

• Allele Symbol: Kcnip2^tm1Jmn
• Allele Name: targeted mutation 1, Jeanne Nerbonne
• Allele ID: MGI:5613711
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnip2^tm1Jmn/Kcnip2^tm1Jmn	B6.129-Kcnip2^tm1Jmn	MGI:5613715

Genotype
MGI:5613715

hm1

• Allelic Composition: Kcnip2^tm1Jmn/Kcnip2^tm1Jmn
• Genetic Background: B6.129-Kcnip2^tm1Jmn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:214199 )

N • electrocardiogram waveforms are normal

abnormal myocardial fiber physiology ( J:214199 )

• ventricular myocytes exhibit elimination of fast transient outward potassium current remodelling compared with wild-type cells

• the waveforms of voltage-gated potassium channel currents recorded at room temperature are unique

• reintroduction of the endogenous protein does not rescue fast transient outward potassium current

• however, inward rectifying currents are normal