Phenotypes associated with this allele

• Allele Symbol: Ptprc^m1Smv
• Allele Name: mutation 1, Silvia M Vidal
• Allele ID: MGI:5613813
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^m1Smv/Ptprc^m1Smv	involves: C57BL/6J * C57BL/10J	MGI:5696745

Genotype
MGI:5696745

hm1

• Allelic Composition: Ptprc^m1Smv/Ptprc^m1Smv
• Genetic Background: involves: C57BL/6J * C57BL/10J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system cell morphology ( J:214487 )

decreased DN4 thymocyte number ( J:214487 )

abnormal CD4-positive T cell differentiation ( J:214487 )

• lack of CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:214487 )

• lack of CD8+ T cells

increased double-negative T cell number ( J:214487 )

• increased 4 fold

increased DN3 thymocyte number ( J:214487 )

abnormal immune system physiology ( J:214487 )

CNS inflammation ( J:214487 )

• profound CNS inflammation

increased susceptibility to Herpesvirales infection ( J:214487 )

• homozygotes infected with HSV-1 strain 17 die around 11-13 days after infection while 85% of heterozygous controls survive

• virus titers in the brain are significant by 10 days when spleen and liver titers remain undetectable

hematopoietic system

decreased DN4 thymocyte number ( J:214487 )

abnormal CD4-positive T cell differentiation ( J:214487 )

• lack of CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:214487 )

• lack of CD8+ T cells

increased double-negative T cell number ( J:214487 )

• increased 4 fold

increased DN3 thymocyte number ( J:214487 )

nervous system

CNS inflammation ( J:214487 )

• profound CNS inflammation

endocrine/exocrine glands

decreased DN4 thymocyte number ( J:214487 )

increased DN3 thymocyte number ( J:214487 )