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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnni3ktm1Tfo
targeted mutation 1, Thomas Force
MGI:5613890
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ 		involves: C57BL/6 * FVB/N MGI:5614265
cn2
 		Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/? 		involves: C57BL/6 * FVB/N MGI:6115340


Genotype
MGI:5614265
cn1
Allelic
Composition		 Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Tnni3ktm1Tfo mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:213546 )
N
• tamoxifen-treated mice exhibit normal left ventricle function and cardiac morphometry and normal left ventricular remodeling after permanent occlusion myoinfarction
abnormal myocardial fiber physiology ( J:213546 )
• decreased cell death in tamoxifen-treated mice following ischemic injury
abnormal response to cardiac infarction ( J:213546 )
• following ischemic/reperfusion injury, tamoxifen-treated mice exhibit decreased infarct size and cardiomyocyte cell death compared with wild-type mice
• however, normal left ventricular remodeling after permanent occlusion myoinfarction
decreased myocardial infarct size ( J:213546 )
• in tamoxifen-treated mice following ischemic/reperfusion injury

homeostasis/metabolism
abnormal response to cardiac infarction ( J:213546 )
• following ischemic/reperfusion injury, tamoxifen-treated mice exhibit decreased infarct size and cardiomyocyte cell death compared with wild-type mice
• however, normal left ventricular remodeling after permanent occlusion myoinfarction
decreased myocardial infarct size ( J:213546 )
• in tamoxifen-treated mice following ischemic/reperfusion injury




Genotype
MGI:6115340
cn2
Allelic
Composition		 Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Tnni3ktm1Tfo mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial fiber number ( J:249318 )
• 2.5 fold increase in mononuclear cardiomyocyte frequency
• 3 fold increase in mononuclear diploid cardiomyocytes (MNDCMs)

muscle
increased myocardial fiber number ( J:249318 )
• 2.5 fold increase in mononuclear cardiomyocyte frequency
• 3 fold increase in mononuclear diploid cardiomyocytes (MNDCMs)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory