Phenotypes associated with this allele

• Allele Symbol: Mirc36^tm1.1Jcav
• Allele Name: targeted mutation 1.1, Jerome Cavaille
• Allele ID: MGI:5614047
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mirc36^tm1.1Jcav/Mirc36^+	B6.129-Mirc36^tm1.1Jcav	MGI:5614120

Genotype
MGI:5614120

ht1

• Allelic Composition: Mirc36^tm1.1Jcav/Mirc36⁺
• Genetic Background: B6.129-Mirc36^tm1.1Jcav

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:216177 )

N • no embryonic lethality in when mutation is maternally inherited

perinatal lethality, incomplete penetrance ( J:216177 )

• some mice inheriting maternally die at 15-40 hours

• neonatal lethality is rescued by glucose injections

postnatal lethality, incomplete penetrance ( J:216177 )

• 39% of mice inheriting maternally are dead at 3-4 weeks of age

• no further unusual deaths through 8 months at least

growth/size/body

postnatal growth retardation ( J:216177 )

• growth retardation around 3 weeks of age

homeostasis/metabolism

decreased circulating ketone body level ( J:216177 )

• reduced ketone body production in hypoglycemic mice during the first day of life

abnormal glucose homeostasis ( J:216177 )

abnormal insulin secretion ( J:216177 )

• elevated insulin levels at birth

decreased circulating glucose level ( J:216177 )

• blood glucose reduced about 20% at birth in mice inheriting maternally

hypoglycemia ( J:216177 )

• severe hypoglycemia in a subset of day old mice while the remainder are near normal

increased liver glycogen level ( J:216177 )

• 50% elevation of liver glycogen at birth

behavior/neurological

abnormal suckling behavior ( J:216177 )

• reduced suckling in mice inheriting maternally

liver/biliary system

increased liver glycogen level ( J:216177 )

• 50% elevation of liver glycogen at birth

endocrine/exocrine glands

abnormal insulin secretion ( J:216177 )

• elevated insulin levels at birth