All Phenotypes Rad50<tm4.1Jpt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rad50^tm4.1Jpt/Rad50⁺	involves: 129/Sv * C57BL/6	MGI:5614073
ht2	Rad50^tm1Jpt/Rad50^tm4.1Jpt	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:5614074
ht3	Atm^tm1Awb/Atm⁺	involves: 129/Sv * 129S6/SvEvTac * C57BL/6	MGI:5614077
cn4	Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Rad50^tm3Jpt/Rad50^tm4.1Jpt	involves: 129/Sv * C57BL/6	MGI:5614075
cx5	Atm^tm1Awb/Atm^tm1Awb Rad50^tm4.1Jpt/Rad50⁺	involves: 129/Sv * 129S6/SvEvTac * C57BL/6	MGI:5614078
cx6	Rad50^tm4.1Jpt/Rad50⁺ Spo11^tm1Mjn/Spo11^tm1Mjn	involves: 129/Sv * C57BL/6	MGI:5614080

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased liver tumor incidence ( J:209141 )

• multiple liver neoplasms are seen in 37% of mice

• most affected mice present hyperplastic nodules and/or adenomas

increased hepatoblastoma incidence ( J:209141 )

• malignant hepatoblastomas are seen in 10% of mice

increased liver adenoma incidence ( J:209141 )

reproductive system

ovary atrophy ( J:209141 )

abnormal seminiferous tubule morphology ( J:209141 )

• severely reduced cellularity

small testis ( J:209141 )

• 2-fold smaller than in mutant mice heterozygous for Atm^tm1Awb

testicular atrophy ( J:209141 )

abnormal gametogenesis ( J:209141 )

abnormal sperm number ( J:209141 )

• decrease in the number of meiotic cells

abnormal spermatogenesis ( J:209141 )

• increase in the number of primitive precursors, decrease in the number of meiotic cells and no increase in cell death is consistent with a block in spematogonial differentiation

abnormal fertility/fecundity ( J:209141 )

female infertility ( J:209141 )

• 27% of females are infertile

reduced female fertility ( J:209141 )

• 73% of females produce fewer and smaller litters

decreased litter size ( J:209141 )

• 73% of females produce fewer and smaller litters

male infertility ( J:209141 )

• all males are infertile

hematopoietic system

impaired hematopoiesis ( J:209141 )

• a 50% reduction in the colony forming ability of multipotent precursors

abnormal hematopoietic stem cell morphology ( J:209141 )

• altered LSK population with an expansion of the multipotent precursors

• no increase in proximal descendants of the multipotent precursors is detected

nervous system

hydrocephaly ( J:209141 )

• in 27% of mice

neoplasm

increased liver tumor incidence ( J:209141 )

• multiple liver neoplasms are seen in 37% of mice

• most affected mice present hyperplastic nodules and/or adenomas

increased hepatoblastoma incidence ( J:209141 )

• malignant hepatoblastomas are seen in 10% of mice

increased liver adenoma incidence ( J:209141 )

pigmentation

increased foot pad pigmentation ( J:209141 )

increased tail pigmentation ( J:209141 )

increased skin pigmentation ( J:209141 )

• intense skin hyperpigmentation

endocrine/exocrine glands

ovary atrophy ( J:209141 )

abnormal seminiferous tubule morphology ( J:209141 )

• severely reduced cellularity

small testis ( J:209141 )

• 2-fold smaller than in mutant mice heterozygous for Atm^tm1Awb

testicular atrophy ( J:209141 )

limbs/digits/tail

increased foot pad pigmentation ( J:209141 )

increased tail pigmentation ( J:209141 )

integument

increased foot pad pigmentation ( J:209141 )

increased tail pigmentation ( J:209141 )

increased skin pigmentation ( J:209141 )

• intense skin hyperpigmentation

Allelic Composition	Rad50^tm1Jpt/Rad50^tm4.1Jpt
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:209141 )

• no live mice are found at birth

Allelic Composition	Atm^tm1Awb/Atm⁺
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Awb mutation (7 available); any Atm mutation (170 available)
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal seminiferous tubule morphology ( J:209141 )

• cellularity is increased compared to mutant mice wild-type for Atm

abnormal testis size ( J:209141 )

• 2-fold larger than in mutant mice wild-type for Atm

hematopoietic system

hematopoietic system phenotype ( J:209141 )

N	• unlike mutant mice wild-type for Atm, the LSK population is similar to wild-type controls

nervous system

nervous system phenotype ( J:209141 )

N	• unlike mutant mice wild-type for Atm, no mice with hydrocephaly are seen

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:209141 )

• cellularity is increased compared to mutant mice wild-type for Atm

abnormal testis size ( J:209141 )

• 2-fold larger than in mutant mice wild-type for Atm

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Rad50^tm3Jpt/Rad50^tm4.1Jpt
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Rad50^tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:209141 )

• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system

abnormal intestine morphology ( J:209141 )

• intestinal defects are seen by day 9 of tamoxifen treatment

• die of intestinal failure

Allelic Composition	Atm^tm1Awb/Atm^tm1Awb Rad50^tm4.1Jpt/Rad50⁺
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor latency ( J:209141 )

• marked increase in the latency of thymic lymphomas compared to mutant mice wild-type for Rad50

Allelic Composition	Rad50^tm4.1Jpt/Rad50⁺ Spo11^tm1Mjn/Spo11^tm1Mjn
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal seminiferous tubule morphology ( J:209141 )

• severely reduced cellularity

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:209141 )

• severely reduced cellularity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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