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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd19tm1(cre/ERT2)Rsky
targeted mutation 1, Klaus Rajewsky
MGI:5614310
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+
Cd19tm1(cre/ERT2)Rsky/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:5614487
cn2
 		Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7281485


Genotype
MGI:5614487
cn1
Allelic
Composition		 Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+
Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre/ERT2)Rsky mutation (1 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm11(Lmp1)Rsky mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:217520 )
• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice
increased B cell number ( J:217520 )
• CD19+ B cells in tamoxifen-treated mice
• B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice
• however, cell counts return to baseline after 2 weeks and a second application of tamoxifen does not result in another wave of B cell expansion
increased CD4-positive, alpha-beta T cell number ( J:217520 )
• massive expansion in tamoxifen-treated mice
increased CD8-positive, alpha-beta T cell number ( J:217520 )
• massive expansion in tamoxifen-treated mice
increased activated T cell number ( J:217520 )
• in tamoxifen-treated mice
• however, T cell numbers decrease 8 days after tamoxifen application
abnormal T cell physiology ( J:217520 )
• vigorous degranulation when T cells from tamoxifen-treated mice are exposed to LMP1-transduced B cells in vitro

hematopoietic system
enlarged spleen ( J:217520 )
• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice
increased B cell number ( J:217520 )
• CD19+ B cells in tamoxifen-treated mice
• B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice
• however, cell counts return to baseline after 2 weeks and a second application of tamoxifen does not result in another wave of B cell expansion
increased CD4-positive, alpha-beta T cell number ( J:217520 )
• massive expansion in tamoxifen-treated mice
increased CD8-positive, alpha-beta T cell number ( J:217520 )
• massive expansion in tamoxifen-treated mice
increased activated T cell number ( J:217520 )
• in tamoxifen-treated mice
• however, T cell numbers decrease 8 days after tamoxifen application
abnormal T cell physiology ( J:217520 )
• vigorous degranulation when T cells from tamoxifen-treated mice are exposed to LMP1-transduced B cells in vitro

growth/size/body
enlarged spleen ( J:217520 )
• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice




Genotype
MGI:7281485
cn2
Allelic
Composition		 Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre/ERT2)Rsky mutation (1 available); any Cd19 mutation (60 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

immune system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
monoclonal gammopathy of uncertain significance DOID:7442 J:308792




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory