Phenotypes associated with this allele

• Allele Symbol: Chn1^tm1Ito
• Allele Name: targeted mutation 1, Shigeyoshi Itohara
• Allele ID: MGI:5614423
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chn1^tm1Ito/Chn1^tm1.1Ito Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas * C57BL/6NSlc	MGI:5614424
cn2	Chn1^tm1Ito/Chn1^tm1.1Ito Tg(Slc17a6-icre)1Oki/0	involves: C57BL/6 * C57BL/6NSlc	MGI:5614426

Genotype
MGI:5614424

cn1

• Allelic Composition: Chn1^tm1Ito/Chn1^tm1.1Ito; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:209606 )

N • unlike in germ line null mice, the gait is similar to that in wild-type mice

Genotype
MGI:5614426

cn2

• Allelic Composition: Chn1^tm1Ito/Chn1^tm1.1Ito; Tg(Slc17a6-icre)1Oki/0
• Genetic Background: involves: C57BL/6 * C57BL/6NSlc

behavior/neurological

abnormal gait ( J:209606 )

• quadrupedal hopping gait is dominant at all locomotor frequencies

• occasional alternating gait is seen at lower frequencies, occurrence of alternating gait is increased compared to mice heterozygous for Epha4 ^tm1.1Bzh Epha4^tm1.2Bzh and hemizygous for Tg(Slc17a6-icre)1Oki

nervous system

abnormal spinal cord morphology ( J:209606 )

• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus

abnormal nerve fiber response ( J:209606 )

• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity