All Phenotypes Aars1<tm1.1Slac> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aars1^tm1.1Slac
targeted mutation 1.1, Susan L Ackerman
MGI:5614439

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aars1^tm1.1Slac/Aars1^tm1.1Slac	involves: C57BL/6J * FVB/N	MGI:5614644
ht2	Aars1^tm1.1Slac/Aars1⁺	involves: C57BL/6J * FVB/N	MGI:5614643
ht3	Aars1^sti/Aars1^tm1.1Slac	involves: C57BL/6J * FVB/N	MGI:5614646

Allelic Composition	Aars1^tm1.1Slac/Aars1^tm1.1Slac
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aars1^tm1.1Slac mutation (0 available); any Aars1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:216802 )

• no viable E8.5 or E9.5 embryos are seen and 26% of decidua from heterozygous matings at E8.5/9.5 contain embryos that are too reabsorbed for genotyping, suggesting that homozygotes die at an earlier stage

Allelic Composition	Aars1^tm1.1Slac/Aars1⁺
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aars1^tm1.1Slac mutation (0 available); any Aars1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:216802 )

• aged mice show mild loss of cerebellar Purkinje cells

Allelic Composition	Aars1^sti/Aars1^tm1.1Slac
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aars1^sti mutation (1 available); any Aars1 mutation (69 available)
Aars1^tm1.1Slac mutation (0 available); any Aars1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:216802 )

• ubiquitin and p62-positive puncta are seen in cardiomyocytes

cardiac fibrosis ( J:216802 )

• widespread myocardial fibrosis at 4 months of age

growth/size/body

decreased body size ( J:216802 )

• small body size

integument

alopecia ( J:216802 )

• dorsal alopecia

muscle

abnormal myocardial fiber morphology ( J:216802 )

• ubiquitin and p62-positive puncta are seen in cardiomyocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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