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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ripk1tm1Geno
targeted mutation 1, Genoway
MGI:5614572
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ripk1tm1Geno/Ripk1tm1Geno involves: C57BL/6 MGI:5614628
cx2
 		Ripk1tm1Geno/Ripk1tm1Geno
Ripk3tm2Vmd/Ripk3tm2Vmd 		involves: C57BL/6 * C57BL/6N MGI:5614632


Genotype
MGI:5614628
hm1
Allelic
Composition		 Ripk1tm1Geno/Ripk1tm1Geno
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1tm1Geno mutation (0 available); any Ripk1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:209137 )
• bone marrow-derived marcrophages are resistant to TNF-zVAD induced necroptosis

homeostasis/metabolism
abnormal body temperature ( J:209137 )
• mice exhibit less hypothermia than wild-type mice in response to TNF

mortality/aging
mortality/aging ( J:209137 )
N
• mice are viable




Genotype
MGI:5614632
cx2
Allelic
Composition		 Ripk1tm1Geno/Ripk1tm1Geno
Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1tm1Geno mutation (0 available); any Ripk1 mutation (33 available)
Ripk3tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory