All Phenotypes Casp8<tm1.1Vmd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Casp8^tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5614580

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp8^tm1.1Vmd/Casp8^tm1.1Vmd	involves: C57BL/6N	MGI:5614614
cx2	Casp8^tm1.1Vmd/Casp8^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614616
cx3	Casp8^tm1.1Vmd/Casp8⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614618

Allelic Composition	Casp8^tm1.1Vmd/Casp8^tm1.1Vmd
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^tm1.1Vmd mutation (0 available); any Casp8 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:209137 )

• embryos die mid-gestation

Allelic Composition	Casp8^tm1.1Vmd/Casp8^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^tm1.1Vmd mutation (0 available); any Casp8 mutation (43 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:209137 )

increased T cell number ( J:209137 )

• accumulation of T cells expressing the surface markers CD3 and B220

• T cells, however, proliferate normally in response to antibodies to CD3 and CD28

immune system

enlarged spleen ( J:209137 )

increased T cell number ( J:209137 )

• accumulation of T cells expressing the surface markers CD3 and B220

• T cells, however, proliferate normally in response to antibodies to CD3 and CD28

enlarged lymph nodes ( J:209137 )

mortality/aging

mortality/aging ( J:209137 )

N	• mice are viable

growth/size/body

enlarged spleen ( J:209137 )

Allelic Composition	Casp8^tm1.1Vmd/Casp8⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:209137 )

• lethality around E15.5

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