Phenotypes associated with this allele

• Allele Symbol: Mepce^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5614581
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mepce^tm1.1(KOMP)Vlcg/Mepce^tm1.1(KOMP)Vlcg	B6N(Cg)-Mepce^tm1.1(KOMP)Vlcg/J	MGI:5767724
ht2	Mepce^tm1.1(KOMP)Vlcg/Mepce^+	B6N(Cg)-Mepce^tm1.1(KOMP)Vlcg/J	MGI:5888395

Genotype
MGI:5767724

hm1

• Allelic Composition: Mepce^{tm1.1(KOMP)Vlcg}/Mepce^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Mepce^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 14747A-A12

Data Sources

IMPC Data for Mepce

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mepce^{tm1.1(KOMP)Vlcg}/Mepce^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts hatch from the zona with morphologically normal outgrowth colonies.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• early blastocysts are present in Mendelian ratios at E3.5 (10% versus expected 25%, n=29); no embryos are observed at E7.5

• in vitro, blastocysts hatch from the zona pellucida and form morphologically normal outgrowth colonies after 3 days in culture

Genotype
MGI:5888395

ht2

• Allelic Composition: Mepce^{tm1.1(KOMP)Vlcg}/Mepce⁺
• Genetic Background: B6N(Cg)-Mepce^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 14747A-A12

Data Sources

IMPC Data for Mepce

behavior/neurological

increased vertical activity ( J:211773 )

IMPC - JAX