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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ripk1tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5614600
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ripk1tm1.1Vmd/Ripk1tm1.1Vmd involves: C57BL/6N MGI:5614620
cx2
 		Ripk1tm1.1Vmd/Ripk1tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd 		involves: C57BL/6N MGI:5614622
cx3
 		Ripk1tm1.1Vmd/Ripk1+
Ripk3tm2Vmd/Ripk3tm2Vmd 		involves: C57BL/6N MGI:5614623


Genotype
MGI:5614620
hm1
Allelic
Composition		 Ripk1tm1.1Vmd/Ripk1tm1.1Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1tm1.1Vmd mutation (0 available); any Ripk1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:209137 )
• mice die soon after birth

adipose tissue
abnormal brown adipose tissue physiology ( J:209137 )
• cell death is increased in brown adipose tissue

cellular
increased cell death ( J:209137 )
• cell death is increased in the colon, brown adipose tissue, and thymus
increased thymocyte apoptosis ( J:209137 )
• cell death is increased in the thymus

digestive/alimentary system
abnormal intestine morphology ( J:209137 )
• intestinal lesions
abnormal colon morphology ( J:209137 )
• cell death is increased in the colon

endocrine/exocrine glands
increased thymocyte apoptosis ( J:209137 )
• cell death is increased in the thymus

hematopoietic system
increased thymocyte apoptosis ( J:209137 )
• cell death is increased in the thymus

immune system
increased thymocyte apoptosis ( J:209137 )
• cell death is increased in the thymus




Genotype
MGI:5614622
cx2
Allelic
Composition		 Ripk1tm1.1Vmd/Ripk1tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1tm1.1Vmd mutation (0 available); any Ripk1 mutation (33 available)
Ripk3tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:209137 )
• mice die soon after birth

digestive/alimentary system
abnormal intestine morphology ( J:209137 )
• intestinal lesions




Genotype
MGI:5614623
cx3
Allelic
Composition		 Ripk1tm1.1Vmd/Ripk1+
Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1tm1.1Vmd mutation (0 available); any Ripk1 mutation (33 available)
Ripk3tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic cell number ( J:209137 )
• E18.5 mutants contain fewer hematopoietic cells

homeostasis/metabolism
decreased liver glycogen level ( J:209137 )
• in E18.5 mutants

integument
pallor ( J:209137 )
• E18.5 mutants are pale

liver/biliary system
decreased liver glycogen level ( J:209137 )
• in E18.5 mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory