All Phenotypes Ripk3<tm2Vmd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ripk3^tm2Vmd
targeted mutation 2, Vishva M Dixit
MGI:5614606

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614612
cn2	Cflar^tm1Ywh/Cflar^tm1Ywh Gt(ROSA)26Sor^{tm16(cre)Arte}/Gt(ROSA)26Sor⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac	MGI:5614639
cx3	Ripk3^tm2Vmd/Ripk3^tm2Vmd Ticam1^tm1Aki/Ticam1^tm1Aki	involves: 129P2/OlaHsd * C57BL/6N	MGI:5614635
cx4	Cyld^tm1Scs/Cyld^tm1Scs Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:5614636
cx5	Ripk3^tm2Vmd/Ripk3^tm2Vmd Tnfrsf25^tm1Lex/Tnfrsf25^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:5614638
cx6	Ripk1^tm1Geno/Ripk1^tm1Geno Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6 * C57BL/6N	MGI:5614632
cx7	Ripk3^tm2Vmd/Ripk3^tm2Vmd Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: C57BL/6 * C57BL/6N	MGI:5614637
cx8	Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6 * C57BL/6N	MGI:5614634
cx9	Casp8^tm1.1Vmd/Casp8^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614616
cx10	Casp8^tm1.1Vmd/Casp8⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614618
cx11	Ripk1^tm1.1Vmd/Ripk1^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614622
cx12	Ripk1^tm1.1Vmd/Ripk1⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd	involves: C57BL/6N	MGI:5614623
cx13	Ripk3^tm2Vmd/Ripk3^tm2Vmd Zbp1^tm1Aki/Zbp1^tm1Aki	involves: C57BL/6N	MGI:5614633

Allelic Composition	Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• mice die around E11.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:209137 )

• abnormal yolk sac vasculature

• increase in apoptosis in the yolk sac vasculature

embryo

abnormal vitelline vasculature morphology ( J:209137 )

• abnormal yolk sac vasculature

• increase in apoptosis in the yolk sac vasculature

Allelic Composition	Cflar^tm1Ywh/Cflar^tm1Ywh Gt(ROSA)26Sor^{tm16(cre)Arte}/Gt(ROSA)26Sor⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cflar^tm1Ywh mutation (1 available); any Cflar mutation (32 available)
Gt(ROSA)26Sor^{tm16(cre)Arte} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

Allelic Composition	Ripk3^tm2Vmd/Ripk3^tm2Vmd Ticam1^tm1Aki/Ticam1^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
Ticam1^tm1Aki mutation (0 available); any Ticam1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

Allelic Composition	Cyld^tm1Scs/Cyld^tm1Scs Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyld^tm1Scs mutation (0 available); any Cyld mutation (44 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

Allelic Composition	Ripk3^tm2Vmd/Ripk3^tm2Vmd Tnfrsf25^tm1Lex/Tnfrsf25^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
Tnfrsf25^tm1Lex mutation (2 available); any Tnfrsf25 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

Allelic Composition	Ripk1^tm1Geno/Ripk1^tm1Geno Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1^tm1Geno mutation (0 available); any Ripk1 mutation (33 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:209137 )

Allelic Composition	Ripk3^tm2Vmd/Ripk3^tm2Vmd Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
Tnfrsf1a^tm1Imx mutation (6 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

Allelic Composition	Mlkl^tm1.2Wsa/Mlkl^tm1.2Wsa Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlkl^tm1.2Wsa mutation (0 available); any Mlkl mutation (32 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

Allelic Composition	Casp8^tm1.1Vmd/Casp8^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^tm1.1Vmd mutation (0 available); any Casp8 mutation (45 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:209137 )

increased T cell number ( J:209137 )

• accumulation of T cells expressing the surface markers CD3 and B220

• T cells, however, proliferate normally in response to antibodies to CD3 and CD28

immune system

enlarged spleen ( J:209137 )

increased T cell number ( J:209137 )

• accumulation of T cells expressing the surface markers CD3 and B220

• T cells, however, proliferate normally in response to antibodies to CD3 and CD28

enlarged lymph nodes ( J:209137 )

mortality/aging

mortality/aging ( J:209137 )

N	• mice are viable

growth/size/body

enlarged spleen ( J:209137 )

Allelic Composition	Casp8^tm1.1Vmd/Casp8⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:209137 )

• lethality around E15.5

Allelic Composition	Ripk1^tm1.1Vmd/Ripk1^tm1.1Vmd Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk1^tm1.1Vmd mutation (0 available); any Ripk1 mutation (33 available)
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:209137 )

• mice die soon after birth

digestive/alimentary system

abnormal intestine morphology ( J:209137 )

• intestinal lesions

Allelic Composition	Ripk1^tm1.1Vmd/Ripk1⁺ Ripk3^tm2Vmd/Ripk3^tm2Vmd
Genetic Background	involves: C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hematopoietic cell number ( J:209137 )

• E18.5 mutants contain fewer hematopoietic cells

homeostasis/metabolism

decreased liver glycogen level ( J:209137 )

• in E18.5 mutants

integument

pallor ( J:209137 )

• E18.5 mutants are pale

liver/biliary system

decreased liver glycogen level ( J:209137 )

• in E18.5 mutants

Allelic Composition	Ripk3^tm2Vmd/Ripk3^tm2Vmd Zbp1^tm1Aki/Zbp1^tm1Aki
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3^tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
Zbp1^tm1Aki mutation (0 available); any Zbp1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:209137 )

• embryos do not survive beyond around E11.5

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