Phenotypes associated with this allele

• Allele Symbol: Arhgef12^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5614703
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef12^tm1b(KOMP)Wtsi/Arhgef12^tm1b(KOMP)Wtsi	C57BL/6N-Arhgef12^tm1b(KOMP)Wtsi/Tcp	MGI:6288338
ht2	Arhgef12^tm1b(KOMP)Wtsi/Arhgef12^+	C57BL/6N-Arhgef12^tm1b(KOMP)Wtsi/Tcp	MGI:6288337

Genotype
MGI:6288338

hm1

• Allelic Composition: Arhgef12^{tm1b(KOMP)Wtsi}/Arhgef12^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Arhgef12^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0838_1_A07

Data Sources

IMPC Data for Arhgef12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryonic growth retardation ( J:211773 )

♂

IMPC - TCP

abnormal embryo size ( J:211773 )

♂

IMPC - TCP

growth/size/body

embryonic growth retardation ( J:211773 )

♂

IMPC - TCP

abnormal embryo size ( J:211773 )

♂

IMPC - TCP

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6288337

ht2

• Allelic Composition: Arhgef12^{tm1b(KOMP)Wtsi}/Arhgef12⁺
• Genetic Background: C57BL/6N-Arhgef12^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0838_1_A07

Data Sources

IMPC Data for Arhgef12

behavior/neurological

decreased locomotor activity ( J:211773 )

♀

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

abnormal heart shape ( J:211773 )

♂

IMPC - UCD

enlarged heart ( J:211773 )

♂

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

nervous system

increased prepulse inhibition ( J:211773 )

♀

IMPC - UCD