cellular
• mice treated with 1-methylpyrene exhibit decreased benzylic DNA adducts in the liver and kidney compared with wild-type mice that is not as severe as in Sult1a1tm1Glatt homozygotes
• mice treated with 1-methylpyrene exhibit a 2.3-fold increase in colonic DNA adduct levels compared with wild-type mice
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homeostasis/metabolism
• mice treated with 1-methylpyrene exhibit decreased electrophilic 1-sulfooxymethylpyrene plasma levels compared with wild-type mice
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