Phenotypes associated with this allele

• Allele Symbol: Hpse^tm1.2Mdh
• Allele Name: targeted mutation 1.2, Mark D Hulett
• Allele ID: MGI:5615466
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpse^tm1.2Mdh/Hpse^tm1.2Mdh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5615467

Genotype
MGI:5615467

hm1

• Allelic Composition: Hpse^tm1.2Mdh/Hpse^tm1.2Mdh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal dendritic cell chemotaxis ( J:209913 )

• reduction of migration of dermal dendritic cells (both DEC-205-high and DEC-205-low) into the auricular lymph nodes in response to FITC, acetone, and dibutylphthalate

• however, mutants show a similar number of Langerhans cells in the ear epidermis, indicating no defect in dendritic cell colonization at the skin

• culturing epidermal and dermal sheets from the ear from mutants results in the formation of dermal cords similarly to wild-type mice

hematopoietic system

abnormal dendritic cell chemotaxis ( J:209913 )

• reduction of migration of dermal dendritic cells (both DEC-205-high and DEC-205-low) into the auricular lymph nodes in response to FITC, acetone, and dibutylphthalate

• however, mutants show a similar number of Langerhans cells in the ear epidermis, indicating no defect in dendritic cell colonization at the skin

• culturing epidermal and dermal sheets from the ear from mutants results in the formation of dermal cords similarly to wild-type mice

increased eosinophil cell number ( J:209913 )

• relative number of eosinophils is higher

decreased leukocyte cell number ( J:209913 )

• total number of white blood cells is slightly lower

abnormal Langerhans cell morphology ( J:209913 )

• Langerhans cells show an overall reduction in maturation markers and MHC II

impaired eosinophil recruitment ( J:209913 )

• decrease in lung tissue eosinophils in house dust mite-sensitized/challenged mutants

immune system

abnormal dendritic cell chemotaxis ( J:209913 )

• reduction of migration of dermal dendritic cells (both DEC-205-high and DEC-205-low) into the auricular lymph nodes in response to FITC, acetone, and dibutylphthalate

• however, mutants show a similar number of Langerhans cells in the ear epidermis, indicating no defect in dendritic cell colonization at the skin

• culturing epidermal and dermal sheets from the ear from mutants results in the formation of dermal cords similarly to wild-type mice

increased eosinophil cell number ( J:209913 )

• relative number of eosinophils is higher

decreased leukocyte cell number ( J:209913 )

• total number of white blood cells is slightly lower

abnormal Langerhans cell morphology ( J:209913 )

• Langerhans cells show an overall reduction in maturation markers and MHC II

impaired eosinophil recruitment ( J:209913 )

• decrease in lung tissue eosinophils in house dust mite-sensitized/challenged mutants

decreased acute inflammation ( J:209913 )

• house dust mite-induced allergic inflammation is reduced, with house dust mite-sensitized/challenged mutants showing a reduced proportion of conventional dendritic cells in the lungs, attenuated Th2-type cytokine (IL-4, IL-5, and IL-13) expression, decreased lung tissue eosinophils, and decreased numbers of mucus-secreting airway epithelial cells

respiratory system

abnormal lung epithelium morphology ( J:209913 )

• decrease in the numbers of mucus-secreting airway epithelial cells in house dust mite-sensitized/challenged mutants