Phenotypes associated with this allele

• Allele Symbol: Trpc4^tm1.1Clph
• Allele Name: targeted mutation 1.1, David E Clapham
• Allele ID: MGI:5615468
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc4^tm1.1Clph/Trpc4^tm1.1Clph	129S1/Sv-Trpc4^tm1.1Clph	MGI:5615469

Genotype
MGI:5615469

hm1

• Allelic Composition: Trpc4^tm1.1Clph/Trpc4^tm1.1Clph
• Genetic Background: 129S1/Sv-Trpc4^tm1.1Clph

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:209620 )

N • responses in learned fear, acoustic startle reflex, behavioral despair and motor coordination assays are similar to controls

decreased anxiety-related response ( J:209620 )

• enter open arms of an elevated maze more frequently and spend more time in the open arms compared to controls

• spend more time in the center of a well-lit open field, enter the center more frequently and are more active compared to controls

nervous system

nervous system phenotype ( J:209620 )

N • synaptic transmission and long term potentiation in neurons of the lateral nucleus of the amygdala are similar to controls

abnormal single cell response ( J:209620 )

• membrane depolarization in neurons of the lateral nucleus of the amygdala induced by a specific agonist of CCK2 receptors is significantly reduced

decreased excitatory postsynaptic current amplitude ( J:209620 )

• in mGluR-EPSCs from cortical and thalmic inputs in slices at more positive potentials (+40 mV)