About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rad21ltm1Yow
targeted mutation 1, Yoshinori Watanabe
MGI:5615691
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rad21ltm1Yow/Rad21ltm1Yow involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5615708
cx2
Rad21ltm1Yow/Rad21ltm1Yow
Rec8mei8/Rec8mei8
involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5615722
cx3
Rad21ltm1Yow/Rad21ltm1Yow
Sun1tm1Mhan/Sun1tm1Mhan
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5615731
cx4
Rad21ltm1Yow/Rad21ltm1Yow
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5615730


Genotype
MGI:5615708
hm1
Allelic
Composition
Rad21ltm1Yow/Rad21ltm1Yow
Genetic
Background
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Yow mutation (1 available); any Rad21l mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary

reproductive system
• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary
• homolog association in the chromosome arm regions of spermatocytes is largely impaired regardless of the accumulation of bouquet nuclei
• homolog association during the leptotene stage rarely initiates in spermatocytes
• oocytes show delayed progression of meiotic prophase at E18.5
• females arrest at zygotene-like or pachytene-like stage with partially impaired synapsis
• spermatocytes accumulate nuclei at the bouquet stage indicating arrest at the bouquet stage
• sister chromatid cohesion is impaired during the leptotene stage but restored in the zygotene stage
• spermatocytes often arrest in the zygotene-like stage while exhibiting telomere clustering along the nuclear envelope
• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage with aberrant synaptonemal complex formation
• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary
• homozygous females mated with wild-type males over 8-12 months do not produce offspring
• homozygous males mated with wild-type females over 8-12 months do not produce offspring

cellular
• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary
• homolog association in the chromosome arm regions of spermatocytes is largely impaired regardless of the accumulation of bouquet nuclei
• homolog association during the leptotene stage rarely initiates in spermatocytes
• oocytes show delayed progression of meiotic prophase at E18.5
• females arrest at zygotene-like or pachytene-like stage with partially impaired synapsis
• spermatocytes accumulate nuclei at the bouquet stage indicating arrest at the bouquet stage
• sister chromatid cohesion is impaired during the leptotene stage but restored in the zygotene stage
• spermatocytes often arrest in the zygotene-like stage while exhibiting telomere clustering along the nuclear envelope
• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage with aberrant synaptonemal complex formation




Genotype
MGI:5615722
cx2
Allelic
Composition
Rad21ltm1Yow/Rad21ltm1Yow
Rec8mei8/Rec8mei8
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Yow mutation (1 available); any Rad21l mutation (34 available)
Rec8mei8 mutation (1 available); any Rec8 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• males and females do not form either cohesion axes or chromosome axes
• spermatocytes exhibit enhanced bouquet arrest

cellular
• males and females do not form either cohesion axes or chromosome axes
• spermatocytes exhibit enhanced bouquet arrest




Genotype
MGI:5615731
cx3
Allelic
Composition
Rad21ltm1Yow/Rad21ltm1Yow
Sun1tm1Mhan/Sun1tm1Mhan
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Yow mutation (1 available); any Rad21l mutation (34 available)
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5615730
cx4
Allelic
Composition
Rad21ltm1Yow/Rad21ltm1Yow
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Yow mutation (1 available); any Rad21l mutation (34 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• spermatocytes do not show significant homolog association
• spermatocytes exhibit bouquet arrest
• synaptonemal complex formation is largely abolished in spermatocytes

cellular
• spermatocytes do not show significant homolog association
• spermatocytes exhibit bouquet arrest
• synaptonemal complex formation is largely abolished in spermatocytes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory