All Phenotypes Rad21l<tm1Yow> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad21l^tm1Yow/Rad21l^tm1Yow	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5615708
cx2	Rad21l^tm1Yow/Rad21l^tm1Yow Rec8^mei8/Rec8^mei8	involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5615722
cx3	Rad21l^tm1Yow/Rad21l^tm1Yow Sun1^tm1Mhan/Sun1^tm1Mhan	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5615731
cx4	Rad21l^tm1Yow/Rad21l^tm1Yow Spo11^tm1Mjn/Spo11^tm1Mjn	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5615730

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

absent ovarian follicles ( J:209347 )

• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary

small testis ( J:209347 )

decreased testis weight ( J:209347 )

reproductive system

absent oocytes ( J:209347 )

• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary

abnormal meiosis ( J:209347 )

abnormal chromosomal synapsis ( J:209347 )

• homolog association in the chromosome arm regions of spermatocytes is largely impaired regardless of the accumulation of bouquet nuclei

• homolog association during the leptotene stage rarely initiates in spermatocytes

abnormal female meiosis ( J:209347 )

• oocytes show delayed progression of meiotic prophase at E18.5

• females arrest at zygotene-like or pachytene-like stage with partially impaired synapsis

abnormal male meiosis ( J:209347 )

• spermatocytes accumulate nuclei at the bouquet stage indicating arrest at the bouquet stage

• sister chromatid cohesion is impaired during the leptotene stage but restored in the zygotene stage

arrest of male meiosis ( J:209347 )

• spermatocytes often arrest in the zygotene-like stage while exhibiting telomere clustering along the nuclear envelope

abnormal synaptonemal complex ( J:209347 )

• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage with aberrant synaptonemal complex formation

absent ovarian follicles ( J:209347 )

• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary

small testis ( J:209347 )

decreased testis weight ( J:209347 )

female infertility ( J:209347 )

• homozygous females mated with wild-type males over 8-12 months do not produce offspring

male infertility ( J:209347 )

• homozygous males mated with wild-type females over 8-12 months do not produce offspring

cellular

absent oocytes ( J:209347 )

• oocytes or follicles are absent at 5 days and 12 weeks postpartum in the ovary

abnormal meiosis ( J:209347 )

abnormal chromosomal synapsis ( J:209347 )

• homolog association in the chromosome arm regions of spermatocytes is largely impaired regardless of the accumulation of bouquet nuclei

• homolog association during the leptotene stage rarely initiates in spermatocytes

abnormal female meiosis ( J:209347 )

• oocytes show delayed progression of meiotic prophase at E18.5

• females arrest at zygotene-like or pachytene-like stage with partially impaired synapsis

abnormal male meiosis ( J:209347 )

• spermatocytes accumulate nuclei at the bouquet stage indicating arrest at the bouquet stage

• sister chromatid cohesion is impaired during the leptotene stage but restored in the zygotene stage

arrest of male meiosis ( J:209347 )

• spermatocytes often arrest in the zygotene-like stage while exhibiting telomere clustering along the nuclear envelope

abnormal synaptonemal complex ( J:209347 )

• spermatocytes form axial elements but they arrest at the leptotene/zygotene stage with aberrant synaptonemal complex formation

Allelic Composition	Rad21l^tm1Yow/Rad21l^tm1Yow Rec8^mei8/Rec8^mei8
Genetic Background	involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^tm1Yow mutation (1 available); any Rad21l mutation (34 available)
Rec8^mei8 mutation (1 available); any Rec8 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal meiosis ( J:209347 )

• males and females do not form either cohesion axes or chromosome axes

abnormal male meiosis ( J:209347 )

• spermatocytes exhibit enhanced bouquet arrest

cellular

abnormal meiosis ( J:209347 )

• males and females do not form either cohesion axes or chromosome axes

abnormal male meiosis ( J:209347 )

• spermatocytes exhibit enhanced bouquet arrest

Allelic Composition	Rad21l^tm1Yow/Rad21l^tm1Yow Sun1^tm1Mhan/Sun1^tm1Mhan
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^tm1Yow mutation (1 available); any Rad21l mutation (34 available)
Sun1^tm1Mhan mutation (1 available); any Sun1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:209347 )

abnormal male meiosis ( J:209347 )

cellular

abnormal chromosomal synapsis ( J:209347 )

abnormal male meiosis ( J:209347 )

Allelic Composition	Rad21l^tm1Yow/Rad21l^tm1Yow Spo11^tm1Mjn/Spo11^tm1Mjn
Genetic Background	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^tm1Yow mutation (1 available); any Rad21l mutation (34 available)
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:209347 )

• spermatocytes do not show significant homolog association

abnormal male meiosis ( J:209347 )

• spermatocytes exhibit bouquet arrest

abnormal synaptonemal complex ( J:209347 )

• synaptonemal complex formation is largely abolished in spermatocytes

cellular

abnormal chromosomal synapsis ( J:209347 )

• spermatocytes do not show significant homolog association

abnormal male meiosis ( J:209347 )

• spermatocytes exhibit bouquet arrest

abnormal synaptonemal complex ( J:209347 )

• synaptonemal complex formation is largely abolished in spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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