All Phenotypes Rorc<m2Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rorc^m2Btlr
mutation 1, Bruce Beutler
MGI:5615712

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rorc^m2Btlr/Rorc^m2Btlr	C57BL/6J-Rorc^m2Btlr	MGI:5615994

Allelic Composition	Rorc^m2Btlr/Rorc^m2Btlr
Genetic Background	C57BL/6J-Rorc^m2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorc^m2Btlr mutation (0 available); any Rorc mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgM level ( J:217792 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

impaired humoral immune response ( J:217792 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased response to antigen ( J:217792 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system

decreased IgM level ( J:217792 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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