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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PrkcbM3Btlr
mutation 3, Bruce Beutler
MGI:5615714
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PrkcbM3Btlr/PrkcbM3Btlr C57BL/6J-PrkcbM3Btlr MGI:5615991
ht2
 		PrkcbM3Btlr/Prkcb+ C57BL/6J-PrkcbM3Btlr MGI:5615992


Genotype
MGI:5615991
hm1
Allelic
Composition		 PrkcbM3Btlr/PrkcbM3Btlr
Genetic
Background		 C57BL/6J-PrkcbM3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM3Btlr mutation (0 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased response to antigen ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased IgM level ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:5615992
ht2
Allelic
Composition		 PrkcbM3Btlr/Prkcb+
Genetic
Background		 C57BL/6J-PrkcbM3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM3Btlr mutation (0 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased response to antigen ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased IgM level ( J:217793 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory