Phenotypes associated with this allele

• Allele Symbol: Jak3^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5615718
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak3^m1Btlr/Jak3^m1Btlr	C57BL/6J-Jak3^m1Btlr	MGI:5615983

Genotype
MGI:5615983

hm1

• Allelic Composition: Jak3^m1Btlr/Jak3^m1Btlr
• Genetic Background: C57BL/6J-Jak3^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased neutrophil cell number ( J:217795 )

decreased NK cell number ( J:217795 )

abnormal T cell subpopulation ratio ( J:217795 )

• an increase in the CD4+ to CD8+ T cell ratio

increased effector memory CD4-positive, alpha-beta T cell number ( J:217795 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:217795 )

decreased T cell number ( J:217795 )

• reduced frequency

decreased single-positive T cell number ( J:217795 )

• reduced frequency of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

• a decreased frequency of naive CD8+ T cells

increased single-positive T cell number ( J:217795 )

• increased frequency of CD4+ T cells in CD3+ T cells

• an increase in the CD44 mean fluorescence intensity (MFI) on CD4+ T cells

increased IgE level ( J:217795 )

decreased IgG level ( J:217795 )

• T-dependent antibody response to ovalbumin administered with aluminum hydroxide

impaired humoral immune response ( J:217795 )

• T-dependent antibody response to ovalbumin administered with aluminum hydroxide

increased susceptibility to Herpesvirales infection ( J:217795 )

• increased mouse cytomegalovirus (MCMV) viral titer in the liver after MCMV infection

decreased response to antigen ( J:217795 )

• T-dependent antibody response to ovalbumin administered with aluminum hydroxide

hematopoietic system

increased neutrophil cell number ( J:217795 )

decreased NK cell number ( J:217795 )

abnormal T cell subpopulation ratio ( J:217795 )

• an increase in the CD4+ to CD8+ T cell ratio

increased effector memory CD4-positive, alpha-beta T cell number ( J:217795 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:217795 )

decreased T cell number ( J:217795 )

• reduced frequency

decreased single-positive T cell number ( J:217795 )

• reduced frequency of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

• a decreased frequency of naive CD8+ T cells

increased single-positive T cell number ( J:217795 )

• increased frequency of CD4+ T cells in CD3+ T cells

• an increase in the CD44 mean fluorescence intensity (MFI) on CD4+ T cells

increased IgE level ( J:217795 )

decreased IgG level ( J:217795 )

• T-dependent antibody response to ovalbumin administered with aluminum hydroxide