Phenotypes associated with this allele

• Allele Symbol: Adam15^tm2.1Bbl
• Allele Name: targeted mutation 2.1, Carl P Blobel
• Allele ID: MGI:5616076
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam15^tm2.1Bbl/Adam15^tm2.1Bbl	involves: 129 * 129P2/OlaHsd * C57BL/6J * SJL	MGI:5616189

Genotype
MGI:5616189

hm1

• Allelic Composition: Adam15^tm2.1Bbl/Adam15^tm2.1Bbl
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:217858 )

• size of tumors produced by heterotopically injected melanoma cells is reduced as compared to wild-type

abnormal tumor susceptibility ( J:217858 )

• 37.5% of mutant mice produce tumors as compared to 70.6% of wild-type mice

decreased tumor incidence ( J:217858 )

• number of tumors produced by heterotopically injected melanoma cells is reduced as compared to wild-type

vision/eye

abnormal retina morphology ( J:217858 )

abnormal retina inner limiting membrane morphology ( J:217858 )

• mice subjected to oxygen-induced retinopathy (OIR) exhibit an increase in the number of endothelial cell nuclei on the virtual side of the internal limiting membrane

retina gliosis ( J:217858 )

• the number of tufts present in the retina is increased in response to oxygen-induced retinopathy