Phenotypes associated with this allele

• Allele Symbol: Entpd3^tm1.1Mjz
• Allele Name: targeted mutation 1, Mark Zylka
• Allele ID: MGI:5616091
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Entpd3^tm1.1Mjz/Entpd3^tm1.1Mjz	B6.129P2(C3)-Entpd3^tm1.1Mjz	MGI:5791928

Genotype
MGI:5791928

hm1

• Allelic Composition: Entpd3^tm1.1Mjz/Entpd3^tm1.1Mjz
• Genetic Background: B6.129P2(C3)-Entpd3^tm1.1Mjz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:217933 )

N • mice display normal laminar organization of the superficial dorsal horn and show no differences in the density or structure of free nerve endings, Meissner corpuscles, and Merkel cells in skin relative to wild-type controls

N • DRG neurons and lumbar spinal cord sections show no reduction in histochemical staining when ATP, ADP, AMP, or UTP are used as substrates, suggesting that nucleotide hydrolysis is not impaired

N • fast-scan cyclic voltammetry (FSCV) revealed normal adenosine production in the dorsal spinal cord in response to a bolus of ADP

decreased sensory neuron number ( J:217933 )

• mice show a small but significant decrease in the number of NT5E-expressing DRG neurons relative to wild-type controls (30.5% versus 35%)

integument

decreased pruritus ( J:217933 )

• following s.c. injection into the nape of the neck, mice show a 34% reduction in beta-alanine-mediated itch response relative to wild-type controls

• however, histamine- and chloroquine-mediated itch responses are not altered

behavior/neurological

behavior/neurological phenotype ( J:217933 )

N • mice show no major nociceptive or thermoregulatory behavioral deficits, as determined by extensive behavioral and pain assays including tail immersion, hot plate, tail clip, cotton swab, acetone, cold plantar, two-temperature discrimination, and water repulsion assays, the CFA model of inflammatory pain, and the LPA model of neuropathic pain