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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp63tm2.1Aam
targeted mutation 2.1, Alea A Mills
MGI:5616190
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp63tm2.1Aam/Trp63tm2.1Aam Not Specified MGI:5616192
ht2
 		Trp63tm2.1Aam/Trp63tm3Aam involves: 129S7/SvEvBrd MGI:6477405
ht3
 		Trp63tm2.1Aam/Trp63tm3.1Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477408
ht4
 		Trp63tm2.1Aam/Trp63tm3.2Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477410


Genotype
MGI:5616192
hm1
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm2.1Aam
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cellular replicative senescence ( J:158291 )
• Ras-expressing MEFs exhibit enhanced proliferation and compromised oncogene-induced senescence

embryo
embryo phenotype ( J:158291 )
N
• no overt developmental phenotypes are seen

neoplasm
neoplasm ( J:158291 )
N
• no overt tumor phenotypes are seen




Genotype
MGI:6477405
ht2
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3Aam
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 95% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 95% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 95% of neonates exhibit cleft palate

integument
thick dermal layer ( J:294158 )
• dermis is thicker in large areas of the skin
abnormal epidermal layer morphology ( J:294158 )
• epidermis is abnormal with the stratum basale and stratum spinosum affected; thickening of Trp63-, K14-, and K10-expressing layers in patches of the epidermis covering the skin surface

limbs/digits/tail
abnormal limb morphology ( J:294158 )
• 100% of neonates exhibit limb defects, ranging from lack of hindlimbs to single ectrodactyly
ectrodactyly ( J:294158 )
• single ectrodactyly in some neonates




Genotype
MGI:6477408
ht3
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3.1Aam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3.1Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 70% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 70% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 70% of neonates exhibit cleft palate

integument
thick dermal layer ( J:294158 )
• dermis is thicker in large areas of the skin
abnormal epidermal layer morphology ( J:294158 )
• epidermis is abnormal with the stratum basale and stratum spinosum affected
thick epidermis ( J:294158 )
• thickening of Trp63-, K14-, and K10-expressing layers in patches of the epidermis covering the skin surface

limbs/digits/tail
limbs/digits/tail phenotype ( J:294158 )
N
• neonates do not exhibit limb defects




Genotype
MGI:6477410
ht4
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3.2Aam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3.2Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

integument
thick epidermis ( J:294158 )
• neonates exhibit an increase in epidermal thickness

limbs/digits/tail
limbs/digits/tail phenotype ( J:294158 )
N
• neonates do not exhibit limb defects




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory