Phenotypes associated with this allele

• Allele Symbol: Ppm1a^tm1.2Lavi
• Allele Name: targeted mutation 1.2, Sara Lavi
• Allele ID: MGI:5616245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppm1a^tm1.2Lavi/Ppm1a^tm1.2Lavi	B.129(Cg)-Ppm1a^tm1.2Lavi	MGI:5616248

Genotype
MGI:5616248

hm1

• Allelic Composition: Ppm1a^tm1.2Lavi/Ppm1a^tm1.2Lavi
• Genetic Background: B.129(Cg)-Ppm1a^tm1.2Lavi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired wound healing ( J:216372 )

• mice that undergo corneal alkaline burn exhibit impaired wound healing with uncontrolled inflammatory response that is seen as early as 2 days after injury, and show epithelial defects, stromal keratocyte transactivation, central ulceration with degraded stroma, enhanced macrophage and monocyte infiltration, and increased keratocyte differentiation

• by day 22 after corneal injury, mutants show irregularity of the epithelium, inflammation and stromal edema unlike wild-type mice which show proper healing

• injured corneas show delayed epithelial closure

cardiovascular system

increased angiogenesis ( J:216372 )

• plugs from mice injected subcutaneously with Matrigel plugs containing VEGF show a 44% increase in the amount of hemoglobin compared to wild-type plugs, indicating enhanced angiogenesis

• in an ex vivo ring assay, mutant aortas exhibit an increased number of sprouts with longer and more branched extensions, indicating accelerated angiogenesis ex vivo

pathological neovascularization ( J:216372 )

• 22 days after corneal alkaline burn, most mice develop corneal neovascularization; an increase in neovascularization can be seen as early as 7 days after wounding

immune system

increased acute inflammation ( J:216372 )

• mice that undergo corneal alkaline burn exhibit impaired wound healing with uncontrolled inflammatory response that is seen as early as 2 days after injury