Phenotypes associated with this allele

• Allele Symbol: Cdh5^tm6Dvst
• Allele Name: targeted mutation 6, Dietmar Vestweber
• Allele ID: MGI:5617006
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh5^tm6Dvst/Cdh5^tm6Dvst	B6.Cg-Cdh5^tm6Dvst	MGI:5697966

Genotype
MGI:5697966

hm1

• Allelic Composition: Cdh5^tm6Dvst/Cdh5^tm6Dvst
• Genetic Background: B6.Cg-Cdh5^tm6Dvst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular extravasation ( J:209801 )

• extravasation of Evans Blue Dye is similar to controls in mice stimulated with VEGF or histamine

• leakage of fluorescent microspheres from vessels after stimulation with VEGF or histamine is similar to controls

• IL-1Beta induced, or TNF induced, extravasation of neutrophiles reduced to 48% of control levels

• T-cell induced endocytosis of VE-cadherin is reduced by 82%

hematopoietic system

abnormal cellular extravasation ( J:209801 )

• extravasation of Evans Blue Dye is similar to controls in mice stimulated with VEGF or histamine

• leakage of fluorescent microspheres from vessels after stimulation with VEGF or histamine is similar to controls

• IL-1Beta induced, or TNF induced, extravasation of neutrophiles reduced to 48% of control levels

• T-cell induced endocytosis of VE-cadherin is reduced by 82%

immune system

abnormal cellular extravasation ( J:209801 )

• extravasation of Evans Blue Dye is similar to controls in mice stimulated with VEGF or histamine

• leakage of fluorescent microspheres from vessels after stimulation with VEGF or histamine is similar to controls

• IL-1Beta induced, or TNF induced, extravasation of neutrophiles reduced to 48% of control levels

• T-cell induced endocytosis of VE-cadherin is reduced by 82%