All Phenotypes Ikzf1<tm3.1Mbu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Cd79a^tm1(cre)Reth/Cd79a⁺ Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL	MGI:5698683
cn2	Cd79a^tm1(cre)Reth/Cd79a⁺ Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL	MGI:5698681
cn3	Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Il7r^{tm1.1(icre)Hrr}/Il7r⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5698686

Allelic Composition	Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Cd79a^tm1(cre)Reth/Cd79a⁺ Rag2^tm1Fwa/Rag2^tm1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ikzf1^tm3.1Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased pro-B cell number ( J:209928 )

• three fold fewer pro-B cells

immune system

decreased pro-B cell number ( J:209928 )

• three fold fewer pro-B cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:209928 )

increased pro-B cell number ( J:209928 )

• two fold more pro-B cells than in controls

• proliferation of c-Kit^hi pro-B cells is normal

• c-Kit^lo pro-B cells accumulate in the G1-G0 phases of the cell cycle

• cells are smaller with functionally rearranged immunoglobulin mu

• c-Kit^hi pro-B cells expressing immunoglobulin mu are increased

abnormal B cell number ( J:209928 )

• six fold reduction in total B cell number in bone marrow relative to controls

decreased pre-B cell number ( J:209928 )

• nearly complete loss of pre-B cells

neoplasm

neoplasm ( J:209928 )

N	• evidence of B cell leukemias is not observed during a year of observation

immune system

abnormal B cell differentiation ( J:209928 )

increased pro-B cell number ( J:209928 )

• two fold more pro-B cells than in controls

• proliferation of c-Kit^hi pro-B cells is normal

• c-Kit^lo pro-B cells accumulate in the G1-G0 phases of the cell cycle

• cells are smaller with functionally rearranged immunoglobulin mu

• c-Kit^hi pro-B cells expressing immunoglobulin mu are increased

abnormal B cell number ( J:209928 )

• six fold reduction in total B cell number in bone marrow relative to controls

decreased pre-B cell number ( J:209928 )

• nearly complete loss of pre-B cells

Allelic Composition	Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Il7r^{tm1.1(icre)Hrr}/Il7r⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1^tm3.1Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Il7r^{tm1.1(icre)Hrr} mutation (0 available); any Il7r mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:209928 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:209928 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:209928 )

immune system

increased T cell derived lymphoma incidence ( J:209928 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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