Phenotypes associated with this allele

• Allele Symbol: Ipo11^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5617259
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ipo11^tm1.1(KOMP)Vlcg/Ipo11^tm1.1(KOMP)Vlcg	B6N(Cg)-Ipo11^tm1.1(KOMP)Vlcg/J	MGI:5767695
ht2	Ipo11^tm1.1(KOMP)Vlcg/Ipo11^+	B6N(Cg)-Ipo11^tm1.1(KOMP)Vlcg/J	MGI:5759296

Genotype
MGI:5767695

hm1

• Allelic Composition: Ipo11^{tm1.1(KOMP)Vlcg}/Ipo11^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Ipo11^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 14956A-A7

Data Sources

IMPC Data for Ipo11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ipo11^{tm1.1(KOMP)Vlcg}/Ipo11^{tm1.1(KOMP)Vlcg} mice show embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos form a rudimentary egg-cylinder but are smaller and no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E7.5 (37% versus expected 25%, n=19) but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

Genotype
MGI:5759296

ht2

• Allelic Composition: Ipo11^{tm1.1(KOMP)Vlcg}/Ipo11⁺
• Genetic Background: B6N(Cg)-Ipo11^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 14956A-A7

Data Sources

IMPC Data for Ipo11

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - JAX

decreased circulating glucose level ( J:211773 )

IMPC - JAX

decreased circulating iron level ( J:211773 )

♀

IMPC - JAX

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - JAX