About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Havcr2tm1Vlcg
targeted mutation 1, Velocigene
MGI:5617473
Summary 2 genotypes


Genotype
MGI:5703653
hm1
Allelic
Composition		 Havcr2tm1Vlcg/Havcr2tm1Vlcg
Genetic
Background		 B6.129-Havcr2tm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Havcr2tm1Vlcg mutation (0 available); any Havcr2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:209885 )
• after infection with attenuated Listeria monocytogenes expressing OVA
• CD8alphaloCD11ahi cells in peripheral blood and spleen are significantly reduced at 7 and 14 days after infection
• cell numbers are not significantly different from controls at later time points
• reduced cell proliferation but normal cell survival
• cell numbers reduced subsequent to secondary infection with virulent bacteria
decreased interferon-gamma secretion ( J:209885 )
• IFN-gamma producing cells are reduced at 7 and 15 days after infection and pulse with OVA
• also reduced IFN-gamma producing cells after secondary infection with virulent bacteria

hematopoietic system
decreased T cell number ( J:209885 )
• after infection with attenuated Listeria monocytogenes expressing OVA
• CD8alphaloCD11ahi cells in peripheral blood and spleen are significantly reduced at 7 and 14 days after infection
• cell numbers are not significantly different from controls at later time points
• reduced cell proliferation but normal cell survival
• cell numbers reduced subsequent to secondary infection with virulent bacteria




Genotype
MGI:5703655
cx2
Allelic
Composition		 Havcr2tm1Vlcg/Havcr2tm1Vlcg
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 B6.Cg-Havcr2tm1Vlcg Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Havcr2tm1Vlcg mutation (0 available); any Havcr2 mutation (35 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:209885 )
• reduced persistence of CD8alphaloCD11ahi cells
decreased interferon-gamma secretion ( J:209885 )
• IFN-gamma producing cells are reduced at 7 days after infection and pulse with OVA

hematopoietic system
decreased T cell number ( J:209885 )
• reduced persistence of CD8alphaloCD11ahi cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory