Phenotypes associated with this allele

• Allele Symbol: Hist1^tm1Sis
• Allele Name: targeted mutation 1, Shunsuke Ishii
• Allele ID: MGI:5617502
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hist1^tm1Sis/Hist1^tm1Sis	C.129(Cg)-Hist1^tm1Sis	MGI:5698466

Genotype
MGI:5698466

hm1

• Allelic Composition: Hist1^tm1Sis/Hist1^tm1Sis
• Genetic Background: C.129(Cg)-Hist1^tm1Sis

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:210169 )

N • homozygotes produced in expected numbers

N • males and females produced in equal numbers

N • oocyte numbers recovered by superovulation is similar in all genotypes

N • ovary morphology and oocyte chromatin structure are normal

decreased litter size ( J:210169 )

• litter size of females crossed to wild type males is 2.67 pups compared to 7.21 pups from control females

embryo

abnormal blastocyst formation ( J:210169 )

• 41% of oocytes develop to blastocysts compared to 82% for controls

• gene activation in 2 cell embryos as measured by uridine analog incorporation is reduced 50% (incorporation level is 5(% of incorporation in controls)