Phenotypes associated with this allele

• Allele Symbol: Hsph1^tm1Kzn
• Allele Name: targeted mutation 1, Kazuhiro Nagata
• Allele ID: MGI:5617737
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsph1^tm1Kzn/Hsph1^tm1Kzn	B6.129P2-Hsph1^tm1Kzn	MGI:5660626

Genotype
MGI:5660626

hm1

• Allelic Composition: Hsph1^tm1Kzn/Hsph1^tm1Kzn
• Genetic Background: B6.129P2-Hsph1^tm1Kzn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to ischemic brain injury ( J:218516 )

• after 30 minutes of transient middle cerebral artery (MCA) occlusion followed by reperfusion for 24 hours, mice exhibit a significantly decreased infarct size and reduced neurological deficit scores relative to wild-type controls

• however, no apparent abnormalities in nervous system development or brain structure are observed under normal physiological conditions

decreased cerebral infarct size ( J:218516 )

• after 30 minutes of transient MCA occlusion followed by reperfusion for 24 hours, mice display a significantly decreased cerebral infarct area and volume in coronal brain sections relative to wild-type controls

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:218516 )

• after 30 minutes of transient middle cerebral artery (MCA) occlusion followed by reperfusion for 24 hours, mice exhibit a significantly decreased infarct size and reduced neurological deficit scores relative to wild-type controls

• however, no apparent abnormalities in nervous system development or brain structure are observed under normal physiological conditions

decreased cerebral infarct size ( J:218516 )

• after 30 minutes of transient MCA occlusion followed by reperfusion for 24 hours, mice display a significantly decreased cerebral infarct area and volume in coronal brain sections relative to wild-type controls

cellular

abnormal cell physiology ( J:218516 )

• mutant mouse embryonic fibroblasts (MEFs) display an increase in Hsp70 chaperone activity