Phenotypes associated with this allele

• Allele Symbol: Ly6k^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:5618096
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ly6k^tm1Osb/Ly6k^tm1Osb	involves: 129S2/SvPas * C57BL/6NSlc	MGI:5698410

Genotype
MGI:5698410

hm1

• Allelic Composition: Ly6k^tm1Osb/Ly6k^tm1Osb
• Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:210341 )

N • female fertility is normal

N • testicular weight and histology is similar to controls, spermatozoa are morphologically normal and able to undergo the acrosome reaction, and males show successful ejaculation and vaginal plug formation

impaired sperm migration in female genital tract ( J:210341 )

♂ • spermatozoa are unable to migrate from the uterus to the oviduct

♂ • however, sperm directly transferred to the oviduct successfully fertilize eggs

male infertility ( J:210341 )

♂

impaired binding of sperm to zona pellucida ( J:210341 )

♂ • in vitro, the number of spermatozoa binding to the zona pellucida is significantly decreased when tested with cumulus-free eggs, despite frequent collisions

♂ • however, sperm can fertilize cumulus-intact eggs

cellular

impaired sperm migration in female genital tract ( J:210341 )

♂ • spermatozoa are unable to migrate from the uterus to the oviduct

♂ • however, sperm directly transferred to the oviduct successfully fertilize eggs