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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc6a3tm2(HBEGF)Rpa
targeted mutation 2, Richard D Palmiter
MGI:5618169
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Slc6a3tm2(HBEGF)Rpa/Slc6a3+ involves: C57BL/6 MGI:5618170


Genotype
MGI:5618170
ht1
Allelic
Composition		 Slc6a3tm2(HBEGF)Rpa/Slc6a3+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a3tm2(HBEGF)Rpa mutation (0 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
loss of dopaminergic neurons ( J:215916 )
• in DT-treated mice

homeostasis/metabolism
decreased dopamine level ( J:215916 )
• mice injected intramuscularly with diphtheria toxin (DT) exhibit reduced dopamine levels in the striatum
• DT-treated mice exhibit reduced 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the striatum




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory