About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hepacamtm1.2Tjj
targeted mutation 1.2, Thomas J Jentsch
MGI:5618262
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hepacamtm1.2Tjj/Hepacamtm1.2Tjj involves: C57BL/6NTac MGI:5646502
cx2
 		Clcn2tm1Tjj/Clcn2tm1Tjj
Hepacamtm1.2Tjj/Hepacamtm1.2Tjj 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac MGI:5646505
cx3
 		Clcn2tm2.1Tjj/Clcn2tm2.1Tjj
Hepacamtm1.2Tjj/Hepacamtm1.2Tjj 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac MGI:5646507


Genotype
MGI:5646502
hm1
Allelic
Composition		 Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hepacamtm1.2Tjj mutation (0 available); any Hepacam mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:210308 )
• myelin vacuolization that slowly progresses with age
abnormal myelin sheath morphology ( J:210308 )
• myelin vacuolization that slowly progresses with age
• most prominent in fibre tracts of the cerebellum
• vacuolization is largely restricted to the cerebellum even after 1 year of age
• leukodystrophy
abnormal glial cell physiology ( J:210308 )
• abnormal Cl- currents in Bergmann glia
• cell capacitance is increased in Bergmann glia
• current amplitudes normalized to cell capacitance are moderately smaller compared to controls in Bergmann glia
abnormal oligodendrocyte physiology ( J:210308 )
• membrane capacitance is increased




Genotype
MGI:5646505
cx2
Allelic
Composition		 Clcn2tm1Tjj/Clcn2tm1Tjj
Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn2tm1Tjj mutation (0 available); any Clcn2 mutation (40 available)
Hepacamtm1.2Tjj mutation (0 available); any Hepacam mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelin sheath morphology ( J:210308 )
• myelin vacuolization is increased compared to either single homozygote




Genotype
MGI:5646507
cx3
Allelic
Composition		 Clcn2tm2.1Tjj/Clcn2tm2.1Tjj
Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn2tm2.1Tjj mutation (0 available); any Clcn2 mutation (40 available)
Hepacamtm1.2Tjj mutation (0 available); any Hepacam mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelin sheath morphology ( J:210308 )
• myelin vacuolization is increased compared to either single homozygote




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory