Analysis Tools
cardiovascular system
| N |
• heart rate remains unchanged through course of study
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• significant increase in heart weight/body weight and heart weight/total length ratios at 10 weeks of age
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• wall thinning observed at 10 weeks but not at 5 weeks of age
• thinning continues through 25 and 52 weeks
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• at 10 weeks
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• diminished fractional shortening at 10 weeks but not 5 weeks of age
• fractional shortening continues to decline at 25 and 52 weeks
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cellular
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• nuclei are considerably enlarged and binuclei are closer together
• nuclei are less circular
• nuclear abnormalities begin to appear at 1 day of age
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• at 10 weeks of age
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muscle
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• diminished fractional shortening at 10 weeks but not 5 weeks of age
• fractional shortening continues to decline at 25 and 52 weeks
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• at 10 weeks of age
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