Phenotypes associated with this allele

• Allele Symbol: Neb^tm2.1Chen
• Allele Name: targeted mutation 2.1, Ju Chen
• Allele ID: MGI:5618471
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neb^tm2.1Chen/Neb^tm2.1Chen	involves: 129 * Black Swiss	MGI:5827532

Genotype
MGI:5827532

hm1

• Allelic Composition: Neb^tm2.1Chen/Neb^tm2.1Chen
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:211217 )

N • surprisingly, mice exhibit normal skeletal muscle regeneration in response to cardiotoxin and show no detectable histological or ultrastructural alterations in skeletal muscle up to 1 year of age

abnormal muscle electrophysiology ( J:211217 )

• at 2 months of age, analysis of force-frequency relationship in the fifth toe EDL muscle revealed a slight but significant depression in isometric stress production at frequencies of 20-30 Hz but not at frequencies >30 Hz

• frequencies required to achieve 25% and 50%, but not 75%, of maximum isometric stress are slightly increased, indicating slightly blunted sensitivity of skeletal muscle to electrical stimulation in a narrow range of frequencies

• however, no significant changes in peak isometric stress production, passive tensile stress, or Young's modulus are observed

homeostasis/metabolism

increased susceptibility to injury ( J:211217 )

• skeletal muscle is more susceptible to eccentric contraction-induced injury than wild-type muscle, as shown by a greater reduction in isometric stress production across the eccentric exercise bout