About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acacatm1Dejs
targeted mutation 1, David E James
MGI:5618483
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/? 		involves: C57BL/6 * DBA/2 MGI:5702405
cn2
 		Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/? 		involves: C57BL/6 * DBA/2 MGI:5702406


Genotype
MGI:5702405
cn1
Allelic
Composition		 Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acacatm1Dejs mutation (0 available); any Acaca mutation (128 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid metabolism ( J:209886 )
• synthesis of C16:0 and C18:1 fatty acids by Listeria infected T cells is reduced relative to controls
• total quantities of C16:0, C18:0, and C18:1 are not significantly changed 24 hours after activation with Listeria

immune system
immune system phenotype ( J:209886 )
N
• thymocyte T cell profiles are normal
• peripheral B cell numbers are normal
decreased T cell number ( J:209886 )
• CD8+ T cells in spleen and peripheral lymph nodes are dramatically reduced
• significant reductions in CD4+ T cells are also observed
decreased memory T cell number ( J:209886 )
• reduced activated memory T cell numbers
abnormal T cell physiology ( J:209886 )
• reduced survival of peripheral CD8+ T cells
• supplementation of cultured cells with exogenous fatty acids improves survival

hematopoietic system
decreased T cell number ( J:209886 )
• CD8+ T cells in spleen and peripheral lymph nodes are dramatically reduced
• significant reductions in CD4+ T cells are also observed
decreased memory T cell number ( J:209886 )
• reduced activated memory T cell numbers
abnormal T cell physiology ( J:209886 )
• reduced survival of peripheral CD8+ T cells
• supplementation of cultured cells with exogenous fatty acids improves survival




Genotype
MGI:5702406
cn2
Allelic
Composition		 Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acacatm1Dejs mutation (0 available); any Acaca mutation (128 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:209886 )
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced

hematopoietic system
increased T cell proliferation ( J:209886 )
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced

cellular
increased T cell proliferation ( J:209886 )
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory