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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cabp1tm1Alee
targeted mutation 1, Amy Lee
MGI:5618492
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cabp1tm1Alee/Cabp1tm1Alee involves: 129 MGI:6157324
hm2
Cabp1tm1Alee/Cabp1tm1Alee involves: 129 * C57BL/6 MGI:5780462


Genotype
MGI:6157324
hm1
Allelic
Composition
Cabp1tm1Alee/Cabp1tm1Alee
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabp1tm1Alee mutation (0 available); any Cabp1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• morphology of retinal cells, axons and dendrites
• larger and slower response to light flash in retinal OFF transient (OFF T) ganglion cells
• slower response to light flash in retinal OFF sustained (OFF S) ganglion cells
• amplitude of response to light flash in retinal OFF S ganglion cells
• reduction in amplitude of nonlinearity of excitatory synaptic currents in retinal OFF S ganglion cells in response to random noise stimulus
• increase in amplitude of nonlinearity of excitatory synaptic currents in retinal OFF T ganglion cells in response to random noise stimulus
• significantly smaller difference between maximum and minimum excitatory synaptic current evoked by random noise stimulus in retinal OFF S ganglion cells
• significantly larger difference between maximum and minimum excitatory synaptic current evoked by random noise stimulus in retinal OFF T ganglion cells
• stronger spike response to 100% contrast step in retinal OFF T ganglion cells
• response range to random noise stimulus in retinal ON alpha ganglion cells
• slower response kinetics to random noise stimulus in retinal ON alpha ganglion cells
• time to peak and amplitude of b-waves of electroretinograms in response to light stimulus

nervous system
N
• morphology of retinal cells, axons and dendrites




Genotype
MGI:5780462
hm2
Allelic
Composition
Cabp1tm1Alee/Cabp1tm1Alee
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabp1tm1Alee mutation (0 available); any Cabp1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes are viable and fertile and display normal survival and body weight with no apparent physiological or motor deficits





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory