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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il23rtm1.1Ngh
targeted mutation 1.1, Nico Ghilardi
MGI:5619109
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il23rtm1.1Ngh/Il23rtm1.1Ngh involves: C57BL/6 MGI:5692285
cx2
 		Il23rtm1.1Ngh/Il23rtm1.1Ngh
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129S/SvEv * C57BL/6 MGI:5693391


Genotype
MGI:5692285
hm1
Allelic
Composition		 Il23rtm1.1Ngh/Il23rtm1.1Ngh
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23rtm1.1Ngh mutation (0 available); any Il23r mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating interleukin level ( J:216867 )
• low levels of IL22 after DSS treatment
increased circulating interleukin-17 level ( J:216867 )
• increase in levels after DSS treatment is less than for controls
decreased physiological sensitivity to xenobiotic ( J:216867 )
• significantly less weight loss after treatment with Sodium Dextran Sulfate (DSS) than in controls

immune system
decreased susceptibility to induced colitis ( J:216867 )
• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
abnormal circulating interleukin level ( J:216867 )
• low levels of IL22 after DSS treatment
increased circulating interleukin-17 level ( J:216867 )
• increase in levels after DSS treatment is less than for controls

digestive/alimentary system
decreased susceptibility to induced colitis ( J:216867 )
• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia




Genotype
MGI:5693391
cx2
Allelic
Composition		 Il23rtm1.1Ngh/Il23rtm1.1Ngh
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23rtm1.1Ngh mutation (0 available); any Il23r mutation (68 available)
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:216867 )
• 15% weight loss after treatment with 2.5% Sodium Dextran Sulfate (DSS) for 5 days
• fail to recover until 10 days after treatment
• IL22 treatment protects against weight loss

digestive/alimentary system
abnormal large intestine crypts of Lieberkuhn morphology ( J:216867 )
• increased crypt loss and epithelial damage after treatment with 2.5% DSS for 5 days
• IL22 treatment protects against crypt loss
decreased colon length ( J:216867 )
• short colon after treatment with 2.5% DSS for 5 days
• IL22 treatment protects against colon shortening

immune system
abnormal circulating interleukin level ( J:216867 )
• reduced expression of IL22 after DSS treatment
decreased interleukin-17 secretion ( J:216867 )
• reduced expression after DSS treatment

homeostasis/metabolism
abnormal circulating interleukin level ( J:216867 )
• reduced expression of IL22 after DSS treatment

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:216867 )
• increased crypt loss and epithelial damage after treatment with 2.5% DSS for 5 days
• IL22 treatment protects against crypt loss




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory