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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plcg2M2Btlr
mutation 2, Bruce Beutler
MGI:5619131
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plcg2M2Btlr/Plcg2M2Btlr C57BL/6J-Plcg2M2Btlr MGI:5619278
ht2
 		Plcg2M2Btlr/Plcg2+ C57BL/6J-Plcg2M2Btlr MGI:5619279


Genotype
MGI:5619278
hm1
Allelic
Composition		 Plcg2M2Btlr/Plcg2M2Btlr
Genetic
Background		 C57BL/6J-Plcg2M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2M2Btlr mutation (0 available); any Plcg2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:218966 )
• some mice exhibit decreased TNF secretion in response to Toll-like receptor (TLR) ligands poly(I:C) (TLR3) and R848 (TLR7/8)




Genotype
MGI:5619279
ht2
Allelic
Composition		 Plcg2M2Btlr/Plcg2+
Genetic
Background		 C57BL/6J-Plcg2M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2M2Btlr mutation (0 available); any Plcg2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:218966 )
• some mice exhibit decreased TNF secretion in response to Toll-like receptor (TLR) ligands poly(I:C) (TLR3) and R848 (TLR7/8)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory