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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rp2tm1.2Asw
targeted mutation 1.2, Anand Swaroop
MGI:5619358
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rp2tm1.2Asw/Rp2tm1.2Asw involves: 129S/SvEv * C57BL/6 MGI:5619363
ot2
 		Rp2tm1.2Asw/Y involves: 129S/SvEv * C57BL/6 MGI:5620352


Genotype
MGI:5619363
hm1
Allelic
Composition		 Rp2tm1.2Asw/Rp2tm1.2Asw
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rp2tm1.2Asw mutation (0 available); any Rp2 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:214194 )
N
• photoreceptors exhibit a normal 9+0 microtubule arrangement in cilium of photoreceptors
thin retina outer nuclear layer ( J:214194 )
• progressive decrease at 5 and 9 months
• however, thickness is normal at 1 month
abnormal cone electrophysiology ( J:214194 )
• reduced b-wave amplitude at 1, 4 and 7 months
abnormal rod electrophysiology ( J:214194 )
• reduced a- and b-wave amplitudes at 4 and 7 months
• however, amplitudes are normal at 1 month

nervous system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 2 DOID:0110415 OMIM:312600
 J:214194




Genotype
MGI:5620352
ot2
Allelic
Composition		 Rp2tm1.2Asw/Y
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rp2tm1.2Asw mutation (0 available); any Rp2 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system

vision/eye
vision/eye phenotype ( J:214194 )
N
• photoreceptors exhibit a normal 9+0 microtubule arrangement in cilium of photoreceptors
thin retina outer nuclear layer ( J:214194 )
• progressive decrease at 5 and 9 months
• however, thickness is normal at 1 month
abnormal cone electrophysiology ( J:214194 )
• reduced b-wave amplitude at 1, 4 and 7 months
abnormal rod electrophysiology ( J:214194 )
• reduced a- and b-wave amplitudes at 4 and 7 months
• however, amplitudes are normal at 1 month

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 2 DOID:0110415 OMIM:312600
 J:214194




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory