Phenotypes associated with this allele

• Allele Symbol: Vgf^tm3(VGF)Srjs
• Allele Name: targeted mutation 3, Stephen R J Salton
• Allele ID: MGI:5619977
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vgf^tm3(VGF)Srjs/Vgf^tm3(VGF)Srjs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5688363

Genotype
MGI:5688363

hm1

• Allelic Composition: Vgf^tm3(VGF)Srjs/Vgf^tm3(VGF)Srjs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:212045 )

N • homozygotes exhibit normalized blood pressure (SBP, DBP and MAP) relative to mice homozygous for the Vgf^tm1Vlcg allele, indicating rescue of the hypertensive knockout phenotype

N • notably, homozygotes exhibit a small but significant decrease in SBP relative to to mice homozygous for the Vgf^{tm2(VGF*)Srjs} allele which lack several VGF-derived C-terminal peptides, including TLQP-21