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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vgftm2(VGF*)Srjs
targeted mutation 2, Stephen R J Salton
MGI:5619978
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vgftm2(VGF*)Srjs/Vgftm2(VGF*)Srjs involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5688364


Genotype
MGI:5688364
hm1
Allelic
Composition		 Vgftm2(VGF*)Srjs/Vgftm2(VGF*)Srjs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgftm2(VGF*)Srjs mutation (0 available); any Vgf mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:212045 )
N
• homozygotes exhibit normalized SBP, DBP and MAP relative to mice homozygous for the Vgftm1Vlcg allele, indicating rescue of the hypertensive knockout phenotype
• notably, homozygotes exhibit a small but significant increase in SBP relative to mice homozygous for the Vgftm1(VGF)Srjs allele




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory